We are interested in the Ubiquitin System and Organelle Quality Control

​The ubiquitin proteasome system (UPS) and autophagy are  the major regulatory pathways that maintains the homeostasis of the cellular proteome. They control the stability, sub-cellular location and activation of virtually all cellular proteins and organelles. Dysfunction of these systems can lead to the inappropriate accumulation of substrates or damaged organelles causing perturbations in the balance of the proteome. This imbalance is implicated in a wide swath of human diseases from cancer to neurodegeneration.

Thus, understanding how cellular triage systems coordinate protein quality control may identify strategies for therapeutic intervention in many human diseases.

Our group is interested in understanding the mechanisms that regulate protein quality control. We are particularly interested in how the ubiquitin system and autophagy regulate organelle cquality control.

​We employ a range of cell biological, biochemical and proteomic tools to understand how the UPS is dynamically organized. Read more about our on-going projects here