Welcome to the Raman Lab
Tufts University School of Medicine
Graduate School of Biomedical Sciences
The ubiquitin proteasome system (UPS) and autophagy are the major regulatory pathways that maintains the homeostasis of the cellular proteome. They control the stability, sub-cellular location and activation of virtually all cellular proteins and organelles. Dysfunction of these systems can lead to the inappropriate accumulation of substrates or damaged organelles causing perturbations in the balance of the proteome. This imbalance is implicated in a wide swath of human diseases from cancer to neurodegeneration.