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Welcome to the Raman Lab
Tufts University School of Medicine Sackler School of Graduate Biomedical Sciences |
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The Ubiquitin System and Protein Quality Control
The ubiquitin proteasome system (UPS) is the major regulatory pathway that maintains the homeostasis of the cellular proteome. It controls the stability, sub-cellular location and activation of virtually all cellular proteins. Dysfunction of the UPS can lead to the inappropriate accumulation of substrates, perturbation in the balance of the proteome and cellular stress and is implicated in a wide swath of human diseases from cancer to neurodegeneration. Thus, understanding how the UPS system coordinates protein quality control may identify strategies for therapeutic intervention in many human diseases.
Our group is interested in understanding the mechanisms that regulate protein quality control. We are particularly interested in how proteins once ubiquitinated are further processed for degradation. We employ a range of cell biological, biochemical and proteomic tools to understand how the UPS is dynamically organized. Read more about our on-going projects here
Lab News
* Our lab's first paper is published in the July 2018 issue of MCB. It was featured in MCB's Spotlight. Read it here!
*Brittany Ahlstedt joins the lab as our first graduate student.
* Lindsay Ejoh from the BDBS program interns in the lab for the summer.
* Our first R01 is funded! Congrats to everyone who made it happen!
* Our lab's first paper is published in the July 2018 issue of MCB. It was featured in MCB's Spotlight. Read it here!
*Brittany Ahlstedt joins the lab as our first graduate student.
* Lindsay Ejoh from the BDBS program interns in the lab for the summer.
* Our first R01 is funded! Congrats to everyone who made it happen!