The Ubiquitin System and Protein Quality Control

​The ubiquitin proteasome system (UPS) is the major regulatory pathway that maintains the homeostasis of the cellular proteome. It controls the stability, sub-cellular location and activation of virtually all cellular proteins. Dysfunction of the UPS can lead to the inappropriate accumulation of substrates, perturbation in the balance of the proteome and cellular stress and is implicated in a wide swath of human diseases from cancer to neurodegeneration. Thus, understanding how the UPS system coordinates protein quality control may identify strategies for therapeutic intervention in many human diseases.

Our group is interested in understanding the mechanisms that regulate protein quality control. We are particularly interested in how proteins once ubiquitinated are further processed for degradation. We employ a range of cell biological, biochemical and proteomic tools to understand how the UPS is dynamically organized. Read more about our on-going projects here

Lab News
* Rakesh presents his work at the EMBO Proteostasis meeting in Portugal!
* Colin Trepicchio joins the lab for a rotation this summer. Welcome to Colin!
* Jacob Klickstein joins the lab. Welcome to Jacob!
* May 2019: Clarissa Nassar joins the lab for the summer as part of the Building Diversity in the Biomedical Sciences (BDBS) program. Welcome to Clarissa! Learn more about BDBS here.
* May 2019: Congratulations to Siri for winning Second Place at the Annual Tufts Post-doctoral Poster competition!
* April 2019 : Mali is awarded a Research Scholar Grant from the American Cancer Society to study ER quality control in Multiple Myeloma! We are very grateful and excited for this new area of research in our lab.
*  March 2019: Congratulations to Brittany for passing her qualifier!

---