The Ubiquitin System and Protein Quality Control

​The ubiquitin proteasome system (UPS) is the major regulatory pathway that maintains the homeostasis of the cellular proteome. It controls the stability, sub-cellular location and activation of virtually all cellular proteins. Dysfunction of the UPS can lead to the inappropriate accumulation of substrates, perturbation in the balance of the proteome and cellular stress and is implicated in a wide swath of human diseases from cancer to neurodegeneration. Thus, understanding how the UPS system coordinates protein quality control may identify strategies for therapeutic intervention in many human diseases.

Our group is interested in understanding the mechanisms that regulate protein quality control. We are particularly interested in how proteins once ubiquitinated are further processed for degradation. We employ a range of cell biological, biochemical and proteomic tools to understand how the UPS is dynamically organized. Read more about our on-going projects here

Lab News

* 3/15/21 Checkout our new manuscript  identifying a new role of p97-UBXN1 in aggresome formation. Congrats to Siri, Jacob and the Juo lab!

* 3/11/21 Congratulations to Iris for passing her Quals!
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* 10/21/20 Our new paper describing AggreCount, an ImageJ script to quantify cellular aggregates is now online at JBC. Check it out here. Congrats to Jacob and Siri for a great paper and new tool for image analysis!
8/2020 Welcome to our new post-doc Richa Khanna!
* 7/9/20 Jacob passes his Quals, Congrats!
 * 6/30/20 Congratulations to Siri for being awarded  a Natalie V. Zucker Research Center for Women Scholars Award !
* 6/29/20 Congratulations to Rakesh and Molly Hodul (Juo Lab)  on a collaborative study that has been accepted at JBC. Find the in-press version here.
 * 6/1/20 Iris Montes joins the lab as our third graduate student! Welcome to Iris.

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